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. Author manuscript; available in PMC: 2018 Nov 28.
Published in final edited form as: Pediatr Res. 2018 May 28;84(2):296–305. doi: 10.1038/s41390-018-0060-6

Table 5.

Predicted pathways activated by mucoid or serous specific protein datasets using IPA.

Mucoid Pathway Serous
Pathway P-value Overlap Pathway P-value Overlap
Phagosome maturation 2.8E-18 16.7% Extrinsic prothrombin activation pathway 9.69E-5 12.5%
Antigen presentation pathway 3.13E-15 32.4% Intrinsic prothrombin activation pathway 3.25E-4 6.9%
Leukocyte extravasation pathway 6.54E-11 8.6% Coagulation system 4.75E-4 5.7%
Integrin signaling 8.3E-11 8.5% Atherosclerosis signaling 5.8E-3 1.6%
Mitochodrial dysfuntion 6.65E-10 8.8% Granulocyte adhesion and diapedesis 1.15E-2 1.1%

The normalized average peptide counts for the mucoid and serous specific datasets were entered in IPA and a core analysis was performed. The top pathways predicted to be activated are shown with associated p values and overlap (percentage of proteins activated in the canonical pathway of IPA).