Table 1.
Genes encoding basement membrane proteins in mice and flies. Data from Flybase, release FB2017_06 [51]
| Basement membrane protein family |
Mouse genes |
Drosophila genes |
|
|---|---|---|---|
| Structural proteins | Laminin | 11 genes | 4 genes |
| α-chain | Lama1 | Laminin A (LanA) | |
| Lama2 | wing blister (wb) | ||
| Lama3 | |||
| Lama4 | |||
| Lama5 | |||
| β-chain | Lamb1 | LanB1 | |
| Lamb2 | |||
| Lamb3 | |||
| γ-chain | Lamc1 | Laminin B2 (LanB2) | |
| Lamc2 | |||
| Lamc3 | |||
|
| |||
| Collagen IV | 6 genes | 2 genes | |
| Collagen IV α1 | Col4a1 | Collagen IV alpha 1 (Col4A1) | |
| Collagen IV α2 | Col4a2 | Viking (vkg) | |
| Collagen IV α3 | Col4a3 | (not present) | |
| Collagen IV α4 | Col4a4 | (not present) | |
| Collagen IV α5 | Col4a5 | (not present) | |
| Collagen IV α6 | Col4a6 | (not present) | |
|
| |||
| Perlecan | 1 gene | 1 gene | |
| Hspg2 | terribly reduced optic lobes (trol) | ||
|
| |||
| Nidogen | 2 genes | 1 gene | |
| Nid1 | Nidogen/entactin (Ndg) | ||
| Nid2 | |||
|
| |||
| Extracellular BM Modifying Enzymes | Matrix Metalloproteinase | 24 genes | 2 genes |
| Mmp1a, Mmp1b, Mmp2, Mmp3, Mmp7, Mmp8, Mmp9, Mmp10, Mmp11, Mmp12, Mmp13, Mmp14, Mmp15, Mmp16, Mmp17, Mmp19, Mmp20, Mmp21, Mmp23, Mmp24, Mmp25, Mmp27, Mmp28, Mmp29 | Matrix metalloproteinase 1 (Mmp1) | ||
| Matrix metalloproteinase 2 (Mmp2) | |||
|
| |||
| Peroxidasin | 1 gene | 1 gene | |
| Pxdn | Peroxidasin (Pxn) | ||
|
| |||
| Lysyl Oxidase | 5 genes | 2 genes | |
| Lox | Lysyl oxidase-like 1 (Loxl1) | ||
| Loxl1 | Lysyl oxidase-like 2 (Loxl2) | ||
| Loxl2 | |||
| Loxl3 | |||
| Loxl4 | |||