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. 2018 Oct 12;13(10):e0205882. doi: 10.1371/journal.pone.0205882

Fig 7. Reactogenicity to vaccine in sensitized vs unsensitized guinea pigs.

Fig 7

Images are representative of guinea pigs inoculated i.n. with C. burnetii (C and D) or unsensitized (saline) (A and B), then challenged with a 2 μg intradermal dose of vaccine (Coxevac) at day 42 p.i.. A) Inflammation at day 7 p.c. in unsensitized guinea pig is multifocal (arrows) and limited to the deep dermis. B) Inflammation at day 21 p.c. in unsensitized guinea pig is similar to day 7 (arrow). C) More severe inflammation with extension through the dermis (arrows) at day 7 p.c. in Cb9M-sensitized guinea pig. D) Progression of inflammation in Cb9M-sensitized guinea pig at day 21 p.c. (arrows) with increased frequency of neutrophils and presence of microabscesses (arrowheads).