Table 2. RMSD of strand A of Pu22 (PDB: 6AU4) to published DNA quadruplex structures.

RMSD (Å)
	c-MYC (NMR, PDB: 1XAV)	c-KIT (X-ray, PDB: 4WO2)	HTelo (X-ray, PDB: 4FXM)
G-quartets*	1.36	6.65	1.03
T1-G2-A3 (5’-head)	4.16	-	-
T20-A21-A22 (3’-tail)	3.45	-	-
T7, T11-A12, T17 (loop)	4.34	-	-
Overall	7.31	10.38	2.78

*G-quartets are comprised of G4-G5-G6, G8-G9-G10, G13-G14-G15, and G17-G18-G19.

RMSD comparisons were not made between distinct quadruplex structures (c-KIT, telomeric) for the loop, head and tail regions due to significant sequence differences.