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. 2018 Oct 10;24(4):593–599.e3. doi: 10.1016/j.chom.2018.09.001

Figure 2.

Figure 2

Neutralizing Antibody Responses to the Superinfecting Envs Did Not Cross-Neutralize the Primary Infecting Envs

(A–D) Neutralizing antibody titers, over time, to the primary infecting (PI, blue) and superinfecting (SI, red) Envs from (A) CAP281, (B) CAP237, (C) CAP256, and (D) CAP377. Titers to Env clones representative of the primary infecting variant circulating near the time of superinfection (CAP281 PI 39w in A and CAP377 PI 37w in D), are shown in light blue and with open symbols.

(E and F) Boost in antibodies specific for V3 peptides following superinfection in donors (E) CAP281 and (F) CAP237. Longitudinal V3 antibody titers were determined by ELISA, using six independent clade C V3 peptides. A peptide found in Ebola virus was used as a negative control. Plotted is the mean and SD.

(G and H) Spike in viral load following superinfection. Longitudinal viral load (in copies per milliliter) is depicted for (G) CAP237 and (H) CAP281. The estimated time of superinfection is shown in each figure by the vertical dotted line with the confidence interval shaded.