Figure 3.
A Single Antibody Response Does Not Account for Neutralization of Both the Primary Infecting and Superinfecting Viruses in Donor CAP377
(A) Introduction of a K169E mutation abrogated neutralization of CAP45 by CAP377, indicating that heterologous neutralization was attributable to a K169-dependent antibody response. Tabled are the ID50 titers for each Env tested against a 2 year plasma sample from CAP377.
(B and C) Introduction of a K169E mutation knocks out neutralization of the superinfecting virus (B), but not the primary infecting virus (C), by CAP377 plasma.
(D) High divergence between the CAP377 primary infecting and superinfecting V2 sequences. Numbers represent reference HXB2 numbering.