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. 2018 Oct 10;24(4):579–592.e4. doi: 10.1016/j.chom.2018.09.003

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© 2018 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Conformations of the gp140 Protomer

(A) Superimpositions of gp120 monomer from the BG505-sCD4-17b-8ANC195 Env trimer structure with gp120s from other Env trimer structures. Left: gp120 monomer from the BG505-sCD4-17b-8ANC195 structure with highlighted structural elements of interest. Right: gp120 from the BG505-sCD4-17b-8ANC195 structure (blue-red colors indicating RMSDs) superimposed with the indicated gp120s (gray).

(B) Superimpositions of gp140 protomer from the BG505-sCD4-17b-8ANC195 Env trimer structure with gp140s from other Env trimer structures. Left: gp140 protomers from the BG505-sCD4-17b-8ANC195 structure with highlighted structural elements of interest (first structure) and highlighted gp120-gp41 interface regions (second structure). Right: gp140 from the BG505-sCD4-17b-8ANC195 structure (blue-red colors indicating RMSDs) superimposed with the indicated gp120s (gray).

See also Figures S5–S7.