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. 2018 Oct 10;24(4):579–592.e4. doi: 10.1016/j.chom.2018.09.003

Figure 4.

Figure 4

Network of Conserved Residues Regulating gp120 Conformational Changes

(A) Bridging-sheet and conserved side-chain conformations in open Env trimer and gp120 monomer structures. Left: topology diagram of 4-stranded bridging sheet. Right: cartoon representations of β20, β21, β2, β3, α1, V1V2, and V3 overlaid on a transparent gp120 monomer surface (top) and stick representations of side chains of conserved residues of corresponding structures (bottom).

(B) Bridging-sheet and conserved side-chain conformations in b12-bound open Env and closed Env trimer structures. Left: topology diagram of 3-stranded bridging sheet. Right: cartoon representations of β20, β21, β2, β3, α1, V1V2, and V3 overlaid on a transparent gp120 monomer surface (top) and stick representations of side chains of conserved residues of corresponding structures (bottom).

See also Figure S4.