Figure 7.

Model for Order of Conformational Changes Leading to Coreceptor Binding and Fusion

(A) Overview of features in different HIV-1 Env trimer conformational states. Five conformations that have been characterized by X-ray crystallography or cryo-EM are listed with their corresponding structural features. (1) PDB: 5T3Z; (2) PDB: 5VN8; (3) PDB: 5VN3; (4) this study; (5) PDB: 1AIK.

(B) Table summarizing structural features of the conformational states listed in (A). coBS, coreceptor binding site; FP, fusion peptide.

See also Video S1.