Fig. 6.
Autophagy inhibitors significantly enhanced anti-cancer efficacy of TNP-1-mediated PTT in the 4T1 model. a, b The body weight (a) and tumor volume (b) changes of mice in the various treatment groups during the 15-day therapeutic period. Dosing used: TNP-1 or TNP-2, 1.5 mg kg−1; CQ, 25 mg kg−1; 3-MA, 100 μmol kg−1. Mean ± s.e.m. n = 5. ***p < 0.001. Student’s t-test. c Photographs of the tumors excised on day 15. d Tumor weight of mice on day 15 in the various treatment groups. Mean ± s.e.m. n = 5. **p < 0.01, ***p < 0.001. Student’s t-test. e Tumor weight of mice in the various treatment groups after a 7-day PTT treatment regimen in a different study. Mean ± s.e.m. n = 6. ***p < 0.001. Student’s t-test. f TUNEL staining (red) of sections from tumor in (e) was performed to show apoptotic cells. Nucleus were stained with DAPI (blue). Scale bar, 50 μm