Fig. 7.
Autophagy inhibitors significantly enhanced anti-cancer efficacy of TNP-1-mediated PTT in the MCF7/MDR model. a Tumor-site temperature recorded after three minute of NIR irradiation, at the various time points after the intravenous injection of TNP-1. Mean ± s.e.m. n = 3. Student’s t-test. b, c The body weight (b) and tumor volume (c) changes of mice in the various treatment groups during the 15-day therapeutic period. Dosing used: TNP-1 or TNP-2, 1.5 mg kg-1; CQ, 25 mg kg−1; Dox, 15 mg kg−1. Mean ± s.e.m. n = 5. ***p < 0.001. Student’s t-test. d Photographs of the tumors excised on day 15. e Tumor weight of mice on day 15 in the various treatment groups. Mean ± s.e.m. n = 5. **p < 0.01, ***p < 0.001. Student’s t-test. f Tumor weight of mice in the various treatment groups after a 7-day PTT treatment regimen in a different study.Mean ± s.e.m.n = 6. ***p < 0.001. Student’s t-test