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. 2018 Oct 12;9(10):1046. doi: 10.1038/s41419-018-1109-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a MethHc database showed that PTGIS has a high DNA methylation levels in BCa compared with normal samples. b Bisulfite sequence analyses of 36 CpG sits of PTGIS promotor region in two BCa cell lines (UM-UC-3 and 5637) and immortalized normal uroepithelial cell line (SV-HUC-1). c qRT-PCR analysis detected the mRNA level of PTGIS in distinct malignancy BCa cells (T24, UM-UC-3, 5637, BIU-87) and immortalized normal uroepithelial cell line (SV-HUC-1). d qRT-PCR analysis detected the mRNA level of PTGIS in UM-UC-3 cells after the treatment by the demethylating agent 5-Aza (Cayman Chemical #11166-5) at 0, 0.5 and 1 μM for 24 h. e qRT-PCR analysis detected the effects of HIF-1A overexpression on PTGIS in SV-HUC-1 cells. f qRT-PCR analysis detected the effects of HIF-1A overexpression on PTGIS in demethylating UM-UC-3 cells (pre-treatment with 1 µM 5Aza for 24 h)