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. 2018 Oct 12;8:15215. doi: 10.1038/s41598-018-33192-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Biological functional performance of the produced bioactive hydrogel marbles and the comparison with non-coated hydrogel spheres (Ctrl). (a) BSA and Ibuprofen accumulative release profiles from the constructs. The inset graphic amplifies the release profiles in the first 24 hours. (b) Slice of the BHM for core imaging purposes to eliminate the shell artifacts. (c) DAPI (on top) and live-dead (at the bottom) fluorescent microscopy images (blue represents nuclei, green represents live cells, and magenta represents dead cells) of MC3T3-E1 cells. Scale bar = 100 µm. The corresponding quantification by image analysis is also shown. The images of non-coated hydrogels (Ctrl) are presented in Fig. S7. (d) Evaluation of the early osteogenic commitment with representative images of ALP staining during the cell culture time and the respective image analysis quantification. Scale bar = 100 µm. When applicable the results are presented as the arithmetic mean ± standard deviation. The images of non-coated hydrogels (Ctrl) are presented in Fig. S8.