Fig. 1.

Structure–activity relationship of DC-34. a Synthesis scheme of MYC G4-binding scaffold. b Table of selected analogs, with the parent compound on the left. %Myc indicates to the percent of MYC protein expressed at a 10 µM dose in L363 MM cells, IC₅₀ is the half maximum concentration for cytotoxicity in L363 MM cells at 48 h, and K_D determined by a fluorescence intensity assay. N. D. indicates that value was not determined