Fig. 7.

Structure of the DC-34/MYC G4 complex indicates an additional stacked layer at each end and rearrangement of the flanking residues. a The 15 lowest energy structures of the DC-34/MYC G4 complex are displayed with a top (left panel), side (middle panel), and bottom (right panel) view relative to the cylindrical axis of the DNA. Residues of MYC G4 from the 5′ G-tetrad and flanking residues are highlighted in light blue, whereas those from the 3′ end are indicated in orange. The two DC-34 molecules are colored green and yellow, and the two potassium ions displayed as purple spheres. b Stereo view of the 15 lowest energy structures of the DC-34/MYC G4 complex