Table 1.
Structural and NMR statistics for the DC-34/MYC G4 complex
| DC-34/MYC G4 | |
|---|---|
| NMR distance and dihedral constraints | |
| Distance constraints | |
| Intramolecular NOEs | 907 |
| Intra-residue | 610 |
| Inter-residue | 297 |
| Sequential (|i – j| = 1) | 253 |
| Medium range (|i – j| ≤ 4) | 22 |
| Long range (|i – j| ≥ 5) | 22 |
| Hydrogen bonds | 27 |
| Intermolecular NOEs | 45 |
| Dihedral angle restraints | |
| χ (O4′-C1′-N9-C4) | 12 |
| G-tetrad planarity (5 atoms sub-groups) | 24 |
| Coordination bond (O6-K+) | 16 |
| Structure statistics | |
| Violations (mean and s.d.) | |
| Distance constraints (Å) | 0 |
| Dihedral angle constraints (°) | 0 |
| Max. dihedral angle violation (°) | 0 |
| Max. distance constraint violation (Å) | 0 |
| Deviations from idealized geometry | |
| Bond lengths (Å) | 0.005 ± 0.000 |
| Bond angles (°) | 0.705 ± 0.005 |
| Impropers (°) | 0.461 ± 0.031 |
| Average pairwise r.m.s.d (Å)a | |
| All atoms | 0.89 ± 0.26 |
| G-tetrads | 0.55 ± 0.12 |
| 5′-end (T4-G5-A6) | 0.29 ± 0.10 |
| 3′-end (T23-A24-A25) | 0.29 ± 0.08 |
aPairwise r.m.s.d. was calculated among 15 refined structures