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. 2018 Oct 12;8:15212. doi: 10.1038/s41598-018-33524-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The microbial family composition in eight individuals before and after TDF-FTC PrEP. Subjects are displayed in the pre-PrEP and post-PrEP panels from left to right as follows: WWS, XNT, WD5, WT9, XRQ, 7RJ, 5FX, and 7NR. The phyla Bacteroidetes and Firmicutes were dominant in all 16 specimens. Prevotellaceae was the most abundant family in all specimens except three pre-PrEP specimens (XNT, 7FX, and 7RJ), with average abundance of 36%. Streptococcaceae was the most abundant family in pre-PrEP sample of participants XNT (51%) and 5FX (17%) and Fusobacteriaceae was the most abundant family in participant 7RJ’s pre-PrEP specimen (40%). The average relative abundance of Lachnospiraceae (11%), Fusobacteriaceae (9.1%), Family_XI (8.8%), and Streptococcaceae (6.6%) were observed to be greater than five percent across 16 specimens from eight participants.