Table 2.

ABCB1 knock-in mouse model comparison

Model	Producer	Insertion site	Insertion	Special features	Ref
Canine ABCB1	genOway	Abcb1a ATP-start codon	Canine cDNA (~4300 bp)	Intended 4 bp deletion with frame shift at pos. TSS +294	[33]
Humanized ABCB1	Taconic	Abcb1a ATP-start codon	Human cDNA (~4300 bp)	Abcb1b knockout	[21]
Humanized ABCB1	genOway	Abcb1a ATP-start codon	Human cDNA (5106 bp)	loxP insertion TSS –492 and TSS +4628	This work

Overview of ABCB1 knock-in mouse models published to date with insertions site of the alien DNA and distinctive features. None of the models express functional ABCB1 proteins.