Fig 5.

Effect of decreased cDNA library sequencing depth on the number of significant connections to target compounds identified that could potentially reverse the disease phenotype. Significant connections to target compounds identified across all cell lines using (A) Dataset_I and (B) Dataset_II gene signatures with subsampling (0.01, 0.1, 0.5, 1) are illustrated in the Venn diagrams. Significant connections to target compounds identified from the neuronal derived cell lines using (C) Dataset_I and (D) Dataset_II across gene signatures are also compared.