Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Sep 13;2:PO.18.00014. doi: 10.1200/PO.18.00014

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 by American Society of Clinical Oncology

Licensed under the Creative Commons Attribution 4.0 License: https://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig A1. — Schematic depicting the bioinformatics pipeline implemented for the subsampling iterative analysis of connectivity mapping for target compound identification. Subsampling using 17 different data fractions (f = 0.01 to 1.0) and 25 iterations per data fraction providing 425 data sets with variable sequencing depth per gene signature. Count vectors were analyzed to detect differentially expressed genes (DEGs) and saved as gene lists. Gene lists were subsequently analyzed in connectivity mapping for target compound identification. RNA-seq analysis measured DEG, gene ontology (GO) terms, and target compound identification for the low- to high- (Dataset_I) and the high- to high-grade (Dataset_II) astrocytoma gene signatures.