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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: J Neurosci Res. 2018 Jul 19;96(12):1900–1913. doi: 10.1002/jnr.24279

Figure 1.

Figure 1.

Effect of GSNO, CAPE, and combination GSNO+CAPE for 7 days on neurobehavioral functions. Treatment of TBI animals with GSNO, CAPE, and GSNO+CAPE improved motor functions (Beam walk; A and foot fault: B), cognitive (NOR, C) and depressive- like behavior (FST; D). Sham animals showed deficits neither in motor nor in cognition and depressive-like behavior. The combination therapy of GSNO+CAPE did not show additional improvement in motor function. However, both cognition and depressive-like behavior were significantly accelerated and greatly improved in the combination group compared with GSNO- or CAPE-treated group. Data are presented as mean+SD (n=8). ***p<0.001 vs. Sham, +++p<0.001, ++p<0.01, +p<0.05 vs. TBI, #p<0.05 vs. GSNO, $p<0.05 and $ $p<0.01 vs. CAPE.