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Major transporters involved in urine concentration in the thick ascending limb (TAL) cell. Na+-K+-2 Cl− cotransporter 2 (NKCC2); renal outer medullary K+ channel (ROMK); Ca++-activated maxi K+ channel (Maxi-K+); K+-Cl− cotransporter 4 (KCC4); Na+-K+-ATPase (NKA); chloride channel (CLC-K2). See text for details.
