Table 3. Tests for mediation of the BMI-genetic risk score (BMI-GRS) to BMI association by Cognitive Restraint.
| BMI-GRS to TFEQ | TFEQ to BMI | BMI-GRS to BMI | BMI-GRS to BMI (adj. for TFEQ) | Sobel test P-val. | Mediation ratio (%) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Effect size (95%CI) | P-val. | Effect size (95%CI) | P-val. | Effect size (95%CI) | P-val. | Effect size (95%CI) | P-val. | |||
| Cognitive restraint (linear term) | ||||||||||
| Men | ||||||||||
| EDEN (n=954) | 0.04 (-0.02, 0.10) | 0.21 | 0.98 (0.76, 1.20) | <1x10-10 | 0.37 (0.15, 0.60) | 1x10-3 | -- | -- | -- | -- |
| Fenland (n=1646) | 0.00 (-0.05, 0.05) | 0.94 | 0.14 (-0.06, 0.35) | 0.17 | 0.79 (0.60, 0.99) | <1x10-10 | -- | -- | -- | -- |
| Women | ||||||||||
| EDEN (n=1200) | 0.10 (0.04, 0.15) | 6x10-4 | 1.62 (1.36, 1.88) | <1x10-10 | 0.80 (0.53, 1.07) | 6x10-9 | 0.65 (0.39, 0.90) | <1x10-10 | 9x10-4 | 19.0% |
| Fenland (n=1869) | 0.07 (0.03, 0.12) | 9x10-4 | 0.10 (-0.15, 0.35) | 0.42 | 0.61 (0.38, 0.85) | 5x10-7 | -- | -- | -- | -- |
| Cognitive restraint (quadratic term) 1 | ||||||||||
| Men | ||||||||||
| EDEN (n=954) | -0.02 (-0.09, 0.04) | 0.51 | -0.34 (-0.55, -0.14) | 9x10-4 | 0.37 (0.15, 0.60) | 1x10-3 | -- | -- | -- | -- |
| Fenland (n=1646) | 0.00 (-0.01, 0.01) | 0.96 | -1.80 (-2.53, -1.07) | 2x10-6 | 0.79 (0.60, 0.99) | <1x10-10 | -- | -- | -- | -- |
| Women | ||||||||||
| EDEN (n=1200) | -0.01 (-0.08, 0.05) | 0.71 | -0.49 (-0.71, -0.27) | 1x10-5 | 0.80 (0.53, 1.07) | 6x10-9 | -- | -- | -- | -- |
| Fenland (n=1869) | -0.01 (-0.02, 0.01) | 0.31 | -2.16 (-3.02, -1.30) | 8x10-7 | 0.61 (0.38, 0.85) | 5x10-7 | -- | -- | -- | -- |
Effect sizes and 95% confidence intervals are from least squares linear regression models. All models were adjusted for age, sex and (in EDEN) recruitment centre
1
Effect estimates refer to the quadratic term. Models were additionally adjusted for the linear term
-- Not applicable. The eating behavior was not associated with both the BMI-GRS and BMI and, as such, could not be considered as a mediator of the association between the BMI-GRS and BMI
The BMI-GRS and TFEQ scores were all standardised to z-scores (mean=0; SD=1)