Table 1. Main transcription factors cooperating with YAP/TAZ.
The biological model in which the ChIP experiments were performed is indicated in brackets, when available. ND: Not determined, hESC: human embryonic stem cell, PDAC: pancreatic ductal adenocarcinoma, SSC: skeletal stem cells, TF: transcription factor.
| YAP/TAZ-TEAD cooperation with other transcription factors. | ||||
|---|---|---|---|---|
| TF | cis-Regulatory element | Biological role and tissue context | Transcriptional effect | Ref |
| AP1 | Enhancer | Tumor proliferation, migration and invasion (A549, HCT116, SK-N-SH, ECC1, MDA-MB-231); chemoresistance; bone metabolism | Activation | 114,116–118 |
| PITX2 | Enhancer/Promoter | Mouse myocardial regeneration upon ischemic injury (P2 mouse ventricle) | Activation | 136 |
| NICD/RBPJ | Enhancer | Trophectoderm lineage specification in mouse blastocyst | Activation | 160 |
| ZEB1 | Promoter | Breast cancer aggressiveness (MDA-MB-231) | Activation | 161 |
| ICD-ERBB4 | ND | Breast cancer cell migration | Activation | 162 |
| E2F | Promoter | Cell cycle progression (S2R+); PDAC proliferation (KrasG12D-driven pancreatic tumors and primary cell cultures) | Activation | 125,127 |
| MYC | Promoter | Cell cycle entry and cell proliferation (3T9MycER fibroblasts) | Activation | 128 |
| SNAIL/SLUG | Promoter | Osteoprogenitors proliferation (SSC-derived osteoblast progenitors) | Activation | 119 |
| p65 | Promoter | Breast cancer cell migration (MCF7) | Activation | 138 |
| NuRD complex | Enhancer | Mesoderm specification of hESCs (hESC) | Inhibition | 163 |
| Promoter | Epithelial cells growth and migration (MCF-10A) | Inhibition | 164,165 | |
| Promoter | Maintenance/Preservation of smooth muscle mesenchymal progenitors (C3H10T1/2) | Inhibition | 166 | |
| SMADs | Enhancer | Mesoderm specification of hESCs (hESC) | Inhibition | 163 |
| YAP/TAZ cooperation with DNA binding platforms | ||||
| RUNX2 | Promoter | Osteogenic differentiation (SSC-derived osteoblast progenitors; C2C12) | Activation | 119,120 |
| p73 | Promoter | DNA-damaged induced apoptosis (HCT119, HEK293) | Activation | 167,168 |
| p53 Mutant | Promoter | Cancer cell proliferation (MDA-MB-468) | Activation | 169 |
| FoxO1 | Promoter | Myocardial response to ischemic injury (H9C2) | Activation | 135 |
| NICD/RBPJ | Enhancer | Embryonic differentiation of neural crest precursors (MDA-231) | Activation | 145 |
| β-catenin/TCF | Promoter/ND | Heart development (E14.5 hearts) | Activation | 73 |
| β-catenin/TBX5 | Promoter | Cancer cell lines pro-survival genes (HuTu80) | Activation | 29 |