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. Author manuscript; available in PMC: 2019 Sep 29.
Published in final edited form as: Annu Rev Virol. 2018 Jun 27;5(1):385–405. doi: 10.1146/annurev-virology-092917-043323

Figure 1.

Figure 1

Domain structure of tripartite motif (TRIM) proteins. The TRIM, consisting of a really interesting new gene (RING) domain, a B-box 1 and/or B-box 2 domain, and a coiled-coil domain (CCD), is followed by distinct C-terminal domains: SPRY-associated domain (PRY), SPIa and the ryanodine receptor domain (SPRY), C-terminal subgroup one signature domain (Cos), fibronectin type 3 domain (FN3), plant homeodomain (PHD), bromodomain (BROMO), acid-rich region (AR), filamin domain, NHL repeats (NHL), transmembrane domain (TM), ADP-ribosylation factor domain (ARF), and meprin and tumor necrosis factor receptor–associated factor homology domain (MATH). Numbers indicate individual TRIM proteins.