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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Nanomedicine. 2018 Apr 14;14(4):1381–1394. doi: 10.1016/j.nano.2018.04.008

Figure 6.

Figure 6

A. Mice treated with siQ only have greater tumor burden than TWIST knockdown mice. Cisplatin and siTWIST treatment eliminated much of the tumor mass as compared to cisplatin alone, but a combination of cisplatin and siTWIST-MSN-HA knockdown yielded the cleanest peritoneal cavity at the conclusion of the experiment. Arrows indicate tumor foci. One representative image shown per group (siQ, siTWIST and cisplatin n=8; siTWIST and siTWIST-HA n=12). B.–E. qPCR results from tumors collected at necropsy. Tumors exhibit loss of TWIST1 (B) and its target genes Vimentin (C) and N-Cadherin (D). In each case, slighty greater knockdown is observed for siTWIST-MSN-HA than siTWIST-MSN alone. E-Cadherin conversely is increased with loss of TWIST (E).