Table 1.

Co-morbidities in aged F344 rats with TBI

	Testicular tumor (%)	Nephropathy (%)	Splenomegaly (%)	Hepatic issues (%)	Pneumonia (%)	Other (%)
Saline (n=6)	6 (100)	4 (67.7)	1 (16.7)	1 (16.7)	0 (0)	1 (16.7)
25 mg/kg (n=9)	8 (88.9)	1 (11.1)	1 (11.1)	2 (22.2)	1 (11.1)	1 (11.1)
50 mg/kg (n=8)	8 (100)	0 (0)	0 (0)	3 (37.5)	1 (12.5)	2 (25)
200 mg/kg (n=9)	8 (88.9)	3 (33.3)	0 (0)	3 (33.3)	1 (11.1)	0 (0)

Incidence of various co-morbidities observed in post-mortem gross necropsy is expressed in absolute numbers and as a percent of the total number of rats necropsied in each group. Necropsy was not performed on the first 4 rats in the study nor on those that died spontaneously before the end of the study on day 14. “Other” co-morbidities included dermal abscess, pancreatic tumors, and abdominal icterus.