Table 1.
Validation of the prognostic value of Clinseq-DK, M, G models in the TCGA cohort
| Model | C-index (95% CI) | Integrated Brier score | iAUC* | HR (95% CI) | Bayes_factor (x vs ELN3 as reference) | Bayes_factor (Clinseq-G vs other model) |
|---|---|---|---|---|---|---|
| ELN | 0.64 (0.55 to 0.73) | 0.19 | 0.65 | NA | NA | 26.78 |
| Li | 0.65 (0.59 to 0.72) | 0.16 | 0.70 | 2.87 (1.77 to 4.67) | 6.09 | 4.41 |
| Patel | 0.68 (0.59 to 0.77) | 0.17 | 0.68 | NA | 8.90 | 5.94 |
| Clinseq-DK | 0.60 (0.53 to 0.67) | 0.18 | 0.63 | 1.80 (1.12 to 2.87) | 0.63 | 34.71 |
| Clinseq-M | 0.56 (0.49 to 0.64) | 0.20 | 0.59 | 0.93 (0.59 to 1.47) | 0.13 | 124.00 |
| Clinseq-G | 0.68 (0.62 to 0.74) | 0.17 | 0.73 | 2.42 (1.51 to 3.88) | 26.78 | NA |
*
Integrated area under the curve of time-dependent receiver operating characteristic. C-index = concordance index; CI = confidence interval; ELN = the European LeukemiaNet risk stratification system; HR = hazard ratio; iAUC = integrated area under the curve; NA = not applicable; TCGA = The Cancer Genome Atlas.