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. 2018 Mar 5;110(10):1084–1093. doi: 10.1093/jnci/djy022

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 2. — Impact of number of breakpoints on patient survival. Comparison of overall survival (A and C) and event-free survival (B and D) of cases with many breakpoints (9–61, above or equal to median) vs cases with a lower number of breakpoints (2–8, below median), within both the subgroup of MYCN-amplified cases (A and B) and the subgroup of MYCN-nonamplified cases (C and D). P values represent two-sided log-rank tests. Curve labels represent the number of samples with the number of events between brackets. EFS = event-free survival; MNA = MYCN-amplified; non-MNA = MYCN-nonamplified; OS = overall survival.