Mechanisms of the involvement of Pes in heart-lung interactions under positive pressure mechanical ventilation. Under mechanical ventilation, the mechanisms of heart-lung interactions can differ greatly in the case of preserved or altered lung compliance. Heart-lung interactions rely on the increase in Ppl and on PTP in patients with preserved or altered compliance, respectively. Paw, airway pressure; LV, left ventricle; MV, mechanical ventilation; Pes, esophageal pressure; Ppl, pleural pressure; PTP, transpulmonary pressure; RA, right atrium; RV, right ventricle; SVC, superior vena cava.