Schematic representation of the relation between the systemic venous return curve, which remains constant, the left ventricular (LV) function curve which moves with changing intrathoracic pressure (ITP) during breathing. Apneic baseline is shown at “A”. With spontaneous inspiration, ITP decreases so does right atrial pressure but cardiac output increases (“B”), whereas, the opposite occurs with positive-pressure inspiration (“C”). ITP, intrathoracic pressure.