Table 5.
SUCRA values for all interventions for each outcome
| FEV1 | TDI score | TDI responder | SGRQ score | SGRQ responder | Adverse events | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 12 weeks | 24 weeks | 12 weeks | 24 weeks | 12 weeks | 24 weeks | 12 weeks | 24 weeks | 12 weeks | 24 weeks | 12 weeks | 24 weeks | |
| Placebo | 2.6 | 6.9 | 2.4 | 9.6 | 1.8 | 10.8 | 0.7 | 6.8 | 1.0 | 2.0 | 25.2 | 62.1 |
| Tio18 | 29.5 | 42.6 | 29.7 | 40.1 | 39.1 | 38.5 | 32.9 | 42.1 | 33.4 | 30.2 | 58.9 | 62.6 |
| Tio5 | 40.8 | 36.1 | 59.5 | NA | NA | NA | 27.4 | 44.6 | NA | 35.2 | 75.4 | NA |
| Acl | 39.6 | 43.6 | 56 | 47.6 | 36.6 | 55.4 | 23.9 | 51.7 | 20.1 | 72.7 | 63.3 | NA |
| Glyco | 39.2 | 49.2 | 36.1 | 54.5 | 58.3 | 61.3 | 50.5 | 61.3 | 48.0 | 32.7 | 49.9 | 72.3 |
| Umec | 72.6 | 53.9 | 42.2 | 43.8 | 58.6 | 34.2 | 68.1 | 68.1 | 38.5 | 38.1 | 31.5 | 29.4 |
| AclForm | 64.5 | 66.8 | NA | 88.4 | 72.8 | 88.7 | NA | 61.6 | 68.2 | 76.9 | NA | 74.8 |
| IndaGlyco | 97.6 | 91.7 | 91.6 | 94.2 | 49.1 | 93.5 | 93.1 | 60.6 | 81.7 | 76.1 | NA | 83.9 |
| TioOlo | 84.2 | 82.8 | 97.8 | NA | NA | NA | 77.0 | 66.1 | 93.4 | 85.0 | 75.8 | NA |
| UmecVil | 93.0 | 93.3 | 71.9 | 53.5 | 85.1 | 54.8 | 65.6 | 69.5 | 62.6 | 60.7 | 56.6 | 33.7 |
| SFC500 | 48.9 | 24.5 | 69.9 | 66.8 | 85.6 | 62.2 | 71.1 | 19.2 | 64.6 | 72.6 | 49.3 | 33.3 |
| SFC250 | 19.4 | 76.9 | 35.7 | NA | NA | NA | 53.0 | NA | NA | NA | 40.0 | 26.2 |
| BudeForm | NA | 17.5 | NA | NA | NA | NA | NA | 60.5 | NA | 48.4 | NA | 23.4 |
| FFVI | 63.0 | 64.0 | NA | NA | NA | NA | 75.6 | 71.9 | 70.7 | NA | 28.8 | 48.5 |
| Ipra | 5.1 | 0.2 | 7.2 | 1.5 | 13.0 | 0.4 | 11.2 | 15.8 | 17.8 | 19.6 | 45.3 | NA |
Note: The probabilities of each treatment being ranked best are represented by their SUCRA values.
Abbreviations: Acl, aclidinium; AclForm, aclidinium/formoterol; BudeForm, budesonide/formoterol; FFVI, fluticasone/vilanterol; Glyco, glycopyrronium; IndaGlyco, indacaterol/glycopyrronium; Ipra, ipratropium; NA, results not available; SFC250, fluticasone/salmeterol 250/50 mcg; SFC500, fluticasone/salmeterol 500/50 mcg; SGRQ, St George’s Respiratory Questionnaire; SUCRA, Surface Under the Cumulative Ranking; TDI, transitional dyspnea index; Tio5, tiotropium 5 mcg; Tio18, tiotropium 18 mcg; TioOlo, tiotropium/olodaterol; Umec, umeclidinium; UmecVil, umeclidinium/vilanterol.