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. 2018 Oct 8;9:1135. doi: 10.3389/fphys.2018.01135

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Copyright © 2018 Lazarus and Harridge.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic showing the effects of exercising below (red), at (green), or above (gold) the Set Point. Any protective effects of moving from gold/green to red are unclear (but overall effects are negative). The progression from red through to green will be an overall positive effect, whilst the progression from red through to gold and being able to fulfill athletic potential in later life is unclear. PAE refers to Physical Activity/Exercise.