Table 1.
Effect of esmolol on hemodynamic and metabolic parameters. Data are expressed as mean ± SD
| Variable | Baseline (T0)(n = 10) | Resuscitated endotoxic shock (T1) (n = 10) | Esmolol (T2) (n = 10) | Stop (T3) (n = 8) | Sign (T0–T1) | Sign (T1–T2) | Sign (T2–T3) | P a |
|---|---|---|---|---|---|---|---|---|
| Systolic arterial pressure (mmHg) | 76 ± 11 | 74 ± 11 | 46 ± 12 | 67 ± 11 | NS | *** | ** | P < 0.001 |
| Diastolic arterial pressure (mmHg) | 49 ± 8 | 48 ± 8 | 32 ± 8 | 43 ± 9 | NS | *** | NS | P < 0.001 |
| RV dP/dt_min (mmHg/sec) | −1.3 ± 0.7 | −1.8 ± 0.5 | −1.4 ± 0.4 | −1.6 ± 0.5 | NS | NS | NS | NS |
| Cardiac index (L/min per m2) | 3.5 ± 1.1 | 4.5 ± 1.5 | 2.4 ± 0.8 | 3.3 ± 0.6 | NS | ** | NS | P < 0.01 |
| Lactate (g/mol) | 1.9 ± 1.3 | 3.5 ± 0.9 | 4.3 ± 1.2 | 4.3 ± 1.2 | * | NS | NS | P < 0.001 |
| Hemoglobin (g/dL) | 4.6 ± 0.6 | 5.5 ± 0.7 | 5.3 ± 0.8 | 5.4 ± 0.7 | * | NS | NS | P < 0.05 |
| Hematocrit (L/L) | 0.22 ± 0 | 0.26 ± 0 | 0.25 ± 0 | 0.25 ± 0 | * | NS | NS | P < 0.05 |
| Urea (mmol/L) | 7.1 ± 1.3 | 7.5 ± 1.5 | 8.2 ± 2.3 | 7.5 ± 1.2 | NS | NS | NS | NS |
| PaCO2 (mmHg) | 43 ± 5.8 | 49 ± 12.6 | 45 ± 4.8 | 47 ± 2.3 | NS | NS | NS | NS |
| PvCO2 (mmHg) | 46 ± 3.9 | 53 ± 13.4 | 51 ± 5.2 | 51 ± 1.5 | NS | NS | NS | NS |
| ScvO2 (%) | 86 ± 4 | 90 ± 4 | 87 ± 5 | 89 ± 4 | NS | NS | NS | NS |
| pH | 7.4 ± 0.06 | 7.3 ± 0.09 | 7.3 ± 0.5 | 7.3 ± 0.08 | * | NS | NS | P < 0.05 |
| Base excess (mmol/L) | 3.4 ± 3.7 | −0.4 ± 3.9 | 0 ± 4.4 | 0 ± 6.6 | NS | NS | NS | NS |
| HCO3 (mmol/L) | 27.8 ± 3.1 | 24.7 ± 2.2 | 24.5 ± 2.0 | 24.3 ± 2.0 | NS | NS | NS | P < 0.05 |
NS, Not significant.
a
Significant changes over time (comparison made using one‐way ANOVA), *= P < 0.05, **= P < 0.01 and ***= P < 0.001.