Table 1.
Differentially expressed genes with differentially methylated CpG sites in endothelial colony forming cells from patients with moyamoya disease
| Direction of change |
Gene symbol | Illumina Beadchip 450K |
Expression change |
Methylation change |
||||
|---|---|---|---|---|---|---|---|---|
| Expression | Methylation | Target ID (Illumina 450K) | UCSC RefGene group* | Fold change | P | Δβ | P | |
| Up | Hypo | APOD | cg05624196 | 5’UTR† | 1.39 | 0.040 | –0.38 | 0.050 |
| cg23720929 | 1st Exon | 1.39 | 0.040 | –0.43 | 0.002 | |||
| FAP | cg04793527 | 5’UTR | 1.40 | 0.009 | –0.63 | 0.004 | ||
| cg08826839 | TSS200 | 1.40 | 0.009 | –0.52 | 0.029 | |||
| LITAF | cg02051924 | TSS1500 | 2.43 | 0.000 | –0.23 | 0.007 | ||
| NUPR1 | cg04492847 | TSS200 | 1.28 | 0.013 | –0.21 | 0.033 | ||
| SORT1 | cg23616212 | TSS1500 | 1.72 | 0.022 | –0.36 | 0.027 | ||
UCSC, University of California, Santa Cruz; APOD, apolipoprotein D; 5’UTR, 5’ untranslated region; FAP, fibroblast activation protein alpha; TSS, transcriptional start site; LITAF, lipopolysacchride induced tumor necrosis factor-alpha factor; NUPR1, nuclear protein 1; SORT1, sortilin 1.
*
UCSC RefGene Group: gene region feature category describing the CpG position, from UCSC, as follows (TSS200 refers to 0–200 bases upstream of the TSS, TSS1500 refers to 200–1500 bases upstream of the TSS);
†
5’UTR refers to within the 5’ untranslated region, between the TSS and the ATG start site.