Fig. 1.

The docked complex of GA-1 with human p65-TAD. Representative molecular model of p65-TAD docked with GA-1 (A) or GA-2 (B). The critical proline in each GA and the critical phenylalanine are highlighted in red and blue, respectively. The distance between the Cβ atoms of the two residues in the interface is shown. (C and D) show Ramachandran plot of GA-1 (C) or GA-2 (D) with the phi and psi angles of the critical proline (in red) suggestive of PPII helical conformation. Abbreviations: TAD, transactivation domain; GA, glucocorticoid induced leucine zipper analog; PPII, polyproline type II.