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. 2018 Oct 5;9:461. doi: 10.3389/fgene.2018.00461

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Copyright © 2018 O’Neill, Liao, Patel and Hammell.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Differential expression analysis of highly abundant sRNAs. (A) Heatmaps depicting all significantly differentially expressed sRNAs per subtype. All heatmaps are row-scaled to lie between –1 and 1, based on the VST normalized count values. P1, P2, R1, and R2 represent 451Lu parental replicates 1 and 2 and 451Lu BRAF Resistant replicates 1 and 2, respectively. (B) Bar plot depicting number of abundant and significantly differentially expressed species with a negative or positive log fold change per subtype. Structural RNA species are collapsed for duplicate tRNAs.