Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Oct 4;9:587. doi: 10.3389/fendo.2018.00587

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Wu, Li, Miao, Ye, Wang, Zhang, Xu, Jiang, Zhao and Yuan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic of the role of lncRNAs in the regulation of osteoblast proliferation. LncRNA-H19, lncRNA–HIF1α-AS1, lncRNA TUG1, lncRNA MEG3, lncRNA MALAT1, lncRNA Linc-ROR, lncRNA HOXA-AS3, lncRNA NONHSAT009968, and lncRNA-POIR are likely involved in this process. In addition, lncRNA-H19 indirectly induces osteoblast proliferation via targeting of miR-675. Potent inhibitors of osteoblast proliferation include lncRNA-ANCR, lncRNA-H19, lncRNA MEG3, and lncRNA TSIX. Furthermore, lncRNA-H19, lncRNA MEG3, and lncRNA TSIX attenuate osteoblast proliferation indirectly via miRNA.