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. 2018 Aug 28;596(20):4923–4944. doi: 10.1113/JP276431

Figure 4. Psychosocial stress induces long‐term anhedonia, which is absent after SCFA supplementation.

Figure 4

A, hedonic and reward‐seeking behaviour was assessed using the female urine sniffing test 2 weeks post stress. B, the expression of genes involved in reward signalling was investigated in the striatum, which were the dopamine receptor D1a (DRD1a), dopamine receptor D2 (DRD2), brain‐derived neurotrophic factor (BDNF Exon IV) and tropomyosin receptor kinase B (TrkB). Data from the female urine sniffing test and BDNF gene expression was non‐parametrically distributed and analysed using the Kruskal‐Wallis test, followed by the Mann‐Whitney test. Gene expression data from all other genes were normally distributed and analysed using a two‐way ANOVA, followed by an LSD post hoc test. Significant differences are depicted as: ** P < 0.01 and *** P < 0.001; Control/Control compared to SCFA/Control or Control/Stress, $ P < 0.05; SCFA/Control compared to SCFA/Stress, # P < 0.05; Control/Stress compared to SCFA/Stress. All data are expressed as means ± SEM (n = 8–10). [Color figure can be viewed at http://wileyonlinelibrary.com]