Figure 1 Caption:

Environmental exposures, as well as behaviors and disease processes, can influence the activities of multiple molecular domains individually or at the systems-level. Epigenomics includes molecules that interact with DNA to regulate gene expression potential, transcriptomics includes expression of RNAs, proteomics includes the expression levels of peptides, and metabolomics includes the activities and interactions of metabolites. While the genomic sequence is biologically inherited, genotype may influence the biological response to certain exposures across multiple domains. SNP = single nucleotide polymorphisms, CNV = copy number variations, CpG = cytosine-phosphate-guanine.