Fig. 4.

KRGE and Rg3 inhibit scratching behaviors induced by CQ. Both KRGE (100 mg/animal) and Rg3 (1.5 mg/animal) were administered orally 30 min before CQ subcutaneous injection (200 μg/site) in the nape. Bouts of scratching were counted right after CQ injection for 1 h. Both KRGE (A, n = 5–6) and Rg3 (C, n = 6–10) pretreatment significantly reduced total bouts of scratching. (B) and (D) show time-course graphs of bouts of scratching at 5-min intervals. Error bars indicate standard deviation. *p < 0.05, **p < 0.01. CQ, chloroquine; KRGE, Korean Red Ginseng Extract.