Table 1.

Target volume comparison between EORTC and RTOG guidelines.

EORTC (EORTC 22981/22961, 26071/22072 (Centric), 26981-22981, and AVAglio)	RTOG (RTOG 0525, 0825, 0913, and AVAglio)
Phase 1 (60 Gy/30 fractions)	Phase 1 (46 Gy/23 fr)
GTV = surgical cavity + contrast T1 enhancing tissue	GTV1 = surgical cavity + contrast T1 enhancing tissue + perilesional edema in T2 or FLAIR
CTV = GTV + 2-cm margin*	CTV1 = GTV1 + 2-cm margin (if no peritumoral edema, CTV is contrast enhancing area + 2.5-cm margin)
PTV = CTV + 3–5-mm margin	PTV1 = CTV1 + 3–5 mm margin
	Phase 2 (boost 14 Gy/7 fr)
	GTV2 = surgical cavity + contrast T1 enhancing tissue
	CTV2 = GTV2 + 2-cm margin
	PTV2 = CTV2 + 3–5 mm margin

AVAglio; EORTC; RTOG; GTV, gross tumor volume; CTV, clinical target volume; PTV, planning target volume.

^*Margins up to 3 cm were allowed in EORTC 22981/22961 and from 1 to 1.5 cm in EORTC 26981-22981.

Source: Adapted from Niyazi M et al. ESTRO-ACROP guideline.²⁹