Fig. 4.

KRGE inhibits activation of p38 MAPK and NF-κB signaling pathways in the spinal cords of EAE rats. Western blot analysis and quantitative results for the protein levels of p-p38 (A), p-ERK (B) and p-JNK (C), p-IκBα (D), and NF-κB/p65 (E) in the spinal cord of EAE rats. Analysis of variance test; #p < 0.01 versus sham group; *p < 0.01 versus EAE group. EAE, experimental autoimmune encephalomyelitis; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; KRGE, Korean Red Ginseng extract; MAPK, mitogen-activated protein kinase; NF-κB, nuclear factor-κB.