KRGE blocks the activation and distribution of p-p38 MAPK in the spinal cords of EAE rats. Spinal cord sections were subjected to double immunofluorescence staining to determine immunofluorescence intensities of p-p38 protein in CD11b- (A–L), GFAP- (M–X), and CD4-immunoreactive cells (Y–AJ) in the white matter of spinal cords of EAE rats. Bar, 100 μm. EAE, experimental autoimmune encephalomyelitis; GFAP, glial fibrillary acidic protein; KRGE, Korean Red Ginseng extract; MAPK, mitogen-activated protein kinase.