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CX-4945 significantly inhibited CK2 phosphorylation in all three CCA cells in a dose-dependent manner. In HuCCT1 and Liv27 cells, only higher doses of CX-4945 (7.5 and 10 µM) inhibited the phospho-mTOR/Total mTOR and phospho- p70 S6K/Total p70 S6K ratios (P < 0.05). In EGI-1 cells on the other hand, CX-4945 increased phospho-mTOR/Total mTOR and phospho- p70 S6K/Total p70 S6K ratios.
