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. 2018 Sep 25;115(41):E9697–E9706. doi: 10.1073/pnas.1806189115

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Copyright © 2018 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — smFISH reveals that the localization patterns of β-actin mRNA vary according to axonal subcompartment. (A) Cartoon representation of the different axonal regions analyzed. (B) A comparison of the density of β-actin mRNA molecules in the growth cone and axon shaft via smFISH shows significantly increased density of β-actin mRNA in the growth cone. (C) No difference between β-actin mRNA RNP stoichiometry was observed in the different subcompartments. N.S. not significant. (D) Histogram of β-actin mRNA stoichiometry. Arrowheads indicate more highly multiplexed copy numbers in the growth cone. (E) Relative density of β-actin mRNA across subcompartments of the same axon shows significant enrichment in the central domain of the growth cone. ***P < 0.0001; paired Student’s t test; n = 63 axons.