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. 2018 Sep 25;115(41):10381–10386. doi: 10.1073/pnas.1809480115

Fig. 1.

Fig. 1.

Axial homeotic transformation, its rescue by retinoid antagonist, and enhanced sensitivity to RA-induced abnormality in SMRTmRID. (A) Schematic diagram of axial transformations in SMRTmRID. Vertebrae are depicted as ovals. Yellow ovals with vv indicate presence of tuberculi anterior. Location of the 14th rib in SMRTmRID is indicated in red. (B) Posterior transformation in cervical vertebrae of SMRTmRID. Filled circles and blue arrows indicate position of tuberculum anterior (TA). Incomplete rib anlages on C7 (54% of SMRTmRID) are indicated by black arrowheads. (C) Anterior transformation of lumbar vertebrae to thoracic. Presence of the 14th rib is indicated by arrowhead. (D) Rescue of cervical transformation in SMRTmRID by RARα antagonist (BMS 204493) treatment at E10.5. WT and SMRTmRID cervical columns are shown after antagonist treatment. (E) Typical cranial abnormality evident in SMRTmRID after exogenous RA exposure at E10 with single dose of 100 mg/kg. Fusion between basioccipital (bo) and exoccipital (eo) bones in SMRTmRID (white arrowheads). (F) Severe caudal truncations in SMRTmRID after RA exposure as in E.