Fig. 8.

FCHSD2 functions as a negative regulator for cancer progression. (A) Cell proliferation abilities were measured in the control, FCHSD2–KD cells, and FCHSD2–KD cells reconstituted with FCHSD2^WT-Myc, FCHSD2^S681A-Myc, or FCHSD2^S681E-Myc. ***P < 0.0005. (B) Representative images of cell migration in the cells as described in A. (Scale bars, 250 μm.) (C) Quantification of migrating cells in B. Data in A and C represent mean ± SEM (n = 3). Two-tailed Student’s t tests were used to assess statistical significance for comparison with siCtrl. *P < 0.05, **P < 0.005. (D) Kaplan–Meier survival analysis of NSCLC patients was performed in FCHSD2 high- and low-expression cohorts.