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. 2018 Sep 20;115(41):E9668–E9677. doi: 10.1073/pnas.1803384115

Fig. 6.

Fig. 6.

Combined treatment with progesterone (P4) and the let-7i inhibitor reversed ischemia-induced suppression of Pgrmc1 and BDNF expression in the penumbra. (A) Representative immunoblots probed for Pgrmc1, pro-BDNF, and mature BDNF. (B) Quantitation graph of relative Pgrmc1 protein ratio to Gapdh (n = 4 to 5 per group). (C) Quantitation graph of relative pro-BDNF protein ratio to Gapdh (n = 4 to 5 per group). (D) Quantitation graph of relative mature BDNF protein ratio to Gapdh (n = 4 to 5 per group). (E) Quantitation graph of relative let-7i expression in ischemic brain (n = 4 to 5 per group). n.s, not significant; **P < 0.01 and *P < 0.05 compared with sham; ###P < 0.01 between the two indicated groups, ##P < 0.05 between the two indicated groups, and #P < 0.05 compared with P4 + scrambled. Data are presented as the mean ± SEM.