Table 1.

Inhibition constants and kinetic rate constants of accumulative inhibition of commercial herbicides for fungal AHASs

Inhibitor	C. albicans				C. neoformans
	Ki, nM	kiapp, min−1	k3, min−1	kiapp/k3	Ki, nM	kiapp, min−1	k3, min−1	kiapp/k3
SU
IE	6.3 ± 0.7	0.33 ± 0.05	3.3 × 10−11	10 × 1010	110.5 ± 10.8	0.17 ± 0.02	0.023	7.4
IM	12.7 ± 1.1	1.10 ± 0.15	0.020	55.0	472.7 ± 25.5	0.17 ± 0.03	0.056	3.0
CE	24.3 ± 2.5	1.00 ± 0.32	0.045	22.2	119.7 ± 4.2	0.73 ± 0.03	0.022	33.0
BSM	29.9 ± 2.7	1.82 ± 0.25	0.064	28.4	NI	—	—	—
ES	69.3 ± 6.9	1.69 ± 0.20	0.082	20.6	NI	—	—	—
CS	570 ± 59	NP	NP	—	769 ± 89 × 103	NP	NP	—
SM	630 ± 51	0.67 ± 0.14	0.081	8.3	NI	—	—	—
TP
MT	0.8 ± 0.1	3.39 ± 0.69	0.023	147.4	65.4 ± 4.9	1.14 ± 0.06	0.029	39.3
DS	1.7 ± 0.8	2.31 ± 0.20	0.071	32.5	901.0 ± 72.9	0.13 ± 0.02	0.007	18.6
PS	2.4 ± 0.3	15.26 ± 3.42	0.074	206.2	331.1 ± 20.0	2.18 ± 0.11	0.037	58.9
CSM	4.6 ± 1.2	3.86 ± 0.54	0.052	74.2	35.3 ± 3.7	0.94 ± 0.06	0.018	52.2
FS	10.1 ± 1.7	5.97 ± 0.40	0.068	87.8	590 ± 41.0	0.67 ± 0.03	0.025	26.8
PYS	212 ± 18	2.26 ± 0.10	0.067	33.7	320 ± 29 × 103	3.99 ± 0.60	5.3 × 10−10	7.5 × 109
FT	773 ± 62	3.78 ± 0.27	0.068	55.6	137 ± 9 × 103	2.00 ± 0.59	1.5 × 10−10	1.4 × 1010
SCT
PC	484 ± 37	1.83 ± 0.28	0.080	22.9	9.4 ± 1.6 × 103	0.19 ± 0.04	3.7 × 10−11	5.1 × 109
TCM	28 ± 6 × 103	21.3 ± 4.4	0.109	195.0	1.2 ± 0.2 × 106	NP	NP	—
PB
BS	2.6 ± 0.3 × 103	NP	NP	—	5.8 ± 0.6 × 106	NP	NP	—
PTB	403 ± 37 × 103	NP	NP	—	765 ± 65 × 103	NP	NP	—
IMI
IQ	716 ± 61 × 103	NP	NP	—	NI	—	—	—
IT	4.3 ± 0.7 × 106	NP	NP	—	NI	—	—	—

BS, bispyribac; CS, chlorsulfuron; CSM, cloransulam methyl; DS, diclosulam; FS, florasulam; IQ, imazaquin; IT, imazethapyr; NI, no inhibition detected; NP, no reversible accumulative inhibition present; PS, penoxsulam; PTB, pyrithiobac; TCM, thiencarbazone methyl.